职称

副教授

学位

博士

电话

15072351579

邮箱

zqy@mail.hzau.edu.cn

政治面貌

中共党员

工作单位

华中农业大学信息学院

研究方向

生物信息学、基于人工智能的药物发现

教育经历

2003/09-2008/06，华中师范大学，化学学院，硕博连读

1999/09-2003/07，安庆师范学院，化学系，本科

主要职历

2019/01- 至今    华中农业大学信息学院，副教授，硕/博导

2014/07-2018/12, 华中农业大学信息学院，副教授，硕导

2016/09-2017/09,  美国费城科技大学  访问学者

2011/01-2014/06，华中农业大学，理学院，副教授，硕导

2010/10-2010/12，华中农业大学，理学院，讲师

2008/07-2010/09，华中农业大学，生命科学技术学院，博士后

科研成果

张青叶副教授，现为农业生物信息湖北省重点实验室固定成员，近年来主要从事基于人工智能的药物设计与筛选、基于多数据整合的药物发现等相关的研究工作，主持国家基金、湖北省技术创新重大项目子课题、中国博士后基金等在Biomedicines，Viruses，J. Combin. Chem.，J. Chem. Inf. Model.，Eur. J. Med. Chem.，FEMS Microbio.Lett. 等期刊上发表SCI论文多篇，已获得授权发明专利6项。

代表性论文：

(1) Yao Ruan †, Xiao-Hui Chen †, Feng Jiang, Yan-Guang Liu, Xiao-Long Liang, Bo-Min Lv, Hong-Yu Zhang, Qing-Ye Zhang *. Agent Clustering Strategy Based on Metabolic Flux Distribution and Transcriptome Expression for Novel Drug Development. Biomedicines 2021, 9, 1640.

(2)  Min-Hui Cao, Bao-He Tang, Yao Ruan, Xiao-Long Liang, Xin-Yi Chu, Zhan-Min Liang, Qing-Ye Zhang*, Hong-Yu Zhang. Development of specific and selective bactericide by introducing exogenous metabolite of pathogenic bacteria. European Journal of Medicinal Chemistry, 2021,225, 113808

(3) Xuan Xu †, Qing‐Ye Zhang *,†, Xin‐Yi Chu, Yuan Quan, Bo‐Min Lv and Hong‐Yu Zhang *. Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge, Viruses 2021, 13, 2117

(4) Liang, Xiao-Long; Liang, Zhan-Min; Wang, Shuo; Chen, Xiao-Hui; Ruan, Yao; Zhang, Qing-Ye*; Zhang, Hong-Yu; An analysis of the mechanism underlying photocatalytic disinfection based on integrated metabolic networks and transcriptional data, Journal of Environmental Sciences, 2020, 92, 28.

(5) Liao, Xuan; Zhang, Qing-Ye*; Xu, Lei; Zhang, Hong-Yu; Potential Targets of Actein Identified by Systems Chemical Biology Methods, ChemMedChem, 2020, 15(6), 473.

其他一作或通讯作者

(6) Cui, Ze-Jia; Zhang, Wei-Tong; Zhu, Qiang*; Zhang, Qing-Ye*; Zhang, Hong-Yu; Using a Heat Diffusion Model to Detect Potential Drug Resistance Genes of Mycobacterium tuberculosis, Protein and Peptide Letters, 2020, 27(8), 711.

(7) Tong, Xin-Yu; Liao, Xuan; Gao, Min; Lv, Bo-Min; Chen, Xiao-Hui; Chu, Xin-Yi*; Zhang, Qing-Ye*; Zhang, Hong-Yu; Identification of NUDT5 Inhibitors From Approved Drugs, FRONTIERS IN MOLECULAR BIOSCIENCES, 2020, 7,44.

(8) Mao Bangqiang; Gao Min; Chen Changshui; Li Zhijun; Zhang Hong Yu; Zhang Qing-Ye*; Design, synthesis and biological evaluation of novel N-nitrophenyl derivatives based on the structure of acetohydroxyacid synthase, Pesticide Biochemistry and Physiology, 2018, 145,100.

(9) Zhang, Qing-Ye*; Chu, Xin-Yi; Jiang, Ling-Han; Liu, Meng-Yuan; Mei, Zhi-Ling; Zhang, Hong-Yu*; Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs, Molecules, 2017, 22(6), 883.

(10) Cui, Ze-Jia; Yang, Qing-Yong; Zhang, Hong-Yu; Zhu, Qiang*; Zhang, Qing-Ye*; Bioinformatics Identification of Drug Resistance-Associated Gene Pairs in Mycobacterium tuberculosis, International Journal of Molecular Sciences, 2016, 17(9), 1417.

(11) Qi Xiaojuan; Tang Wenjie; Gao Shan; Gao Min; Chen Changshui; Zhang Qing-Ye*; Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide, Journal of Chemistry, 2016, 2016, 8583765.

(12) Pei, Zhi-Hua; Xie, Ting; Yang, Qing-Yong*; Zhang, Qing-Ye*; Zhang, Hong-Yu; Novel Isoniazid- and Ethionamide-Resistance Loci in Mycobacterium tuberculosis Identified by Phenome-Wide Association Scans, IEEE International Conference on Bioinformatics and Biomedicine, 2015-11-12.

(13) Zhu, Li-Da; He, Chang-Shou; Liu, Ye-Mao; Quan, Yuan; Chen, Jing; Zhu, Qiang; Zhang, Qing-Ye*; Zhang, Hong-Yu; A Systems Chemical Biology Approach to Identify Targets of Antibacterial Agents: A Case Study of Chelerythrine and Rhein, IEEE International Conference on Bioinformatics and Biomedicine, 2015-11-12.

(14) Xiaojuan Qi; Wenjun Deng; Min Gao; Bangqiang Mao; Shengzhen Xu; Changshui Chen; Qingye Zhang*; Novel lead compound optimization and synthesized based on the target structure of Xanthomonas oryzae pv. oryzae GlmU, Pesticide Biochemistry and Physiology. 2015, 122, 22.

(15) Jin, Jingnan; Qi, Xiaojuan; Yao, Dandan; Mao, Bangqiang; Li, Jianhong; Zhang, Qing-Ye*; Chen, Changshui; Rational Design and Screening Study of Novel Lead Compound Based on Acetohydroxyacid Synthase Structure, Chemical Biology & Drug Design, 2014, 84(3), 316.

(16) Yue, Xia-Li; Li, Hu; Liu, Shuang-Shuang; Zhang, Qing-Ye*; Yao, Jing-Jing; Wang, Fei-Yan; N-Fluorinated phenyl-N '-pyrimidyl urea derivatives: Synthesis, biological evaluation and 3D-QSAR study, Chinese Chemical Letters, 2014, 25(7), 1069.

(17) Wang, Jing#; Zhang, Qing-Ye#; Huang, Zongqing; Liu, Ziduo*; Directed evolution of a family 26 glycoside hydrolase: Endo-beta-1, 4-mannanase from Pantoea agglomerans A021, Journal of Biotechnology, 2013, 167(3), 350.

(18) Jingnan Jin; Hongju Ma; Xiufang Cao; Shengzhen Xu; Jianhong Li; Qingye Zhang*; Changshui Chen*; The discovery of the novel lead compound of N-nitroureas target on acetohydroxyacid synthase, Pesticide Biochemistry and Physiology, 2012, 104(3), 218.

(19) Min, Jun#; Lin, Da#; Zhang, Qing-Ye*; Zhang, Jibing; Yu, Ziniu; Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU, European Journal of Medicinal Chemistry, 2012, 53, 150.

(20) Zhang, Qing-Ye; Yu, Chan; Min, Jun; Wang, Yan; He, Jin; Yu, Ziniu*; Rational questing for potential novel inhibitors of FabK from Streptococcus pneumoniae by combining FMO calculation, CoMFA 3D-QSAR modeling and virtual screening, Journal of Molecular Modeling, 2011, 17(6), 1483.

(21) Min, Jun; Zhang, Xiaoli; Wang, Lei; Zou, Xia; Zhang, Qing-Ye*; He, Jin*; Mutational analysis of the interaction between a potential inhibitor luteolin and enoyl-ACP reductase (FabI) from Salmonella enterica, Journal of Molecular Catalysis B: Enzymatic, 2011, 68(2), 174.

(22) Zhang, Qing-Ye; Li, Ding; Wei, Pei; Zhang, Jie; Wan, Jian; Ren, Yangliang; Chen, Zhigang; Liu, Deli; Yu, Ziniu; Feng, Lingling; Structure-Based Rational Screening of Novel Hit Compounds with Structural Diversity for Cytochrome P450 Sterol 14 alpha-Demethylase from Penicillium digitatum, Journal of Chemical Information and Modeling, 2010, 50(2), 317.

(23) Yao, Jingjing#; Zhang, Qing-Ye#; Min, Jun; He, Jin*; Yu, Ziniu*; Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers, Bioorganic & Medicinal Chemistry Letters, 2010, 20(1), 56.

(24) Zhang, Qing-Ye; Yang, Jiaoyan; Liang, Kun; Feng, Lingling; Li, Sanpin; Wan, Jian; Xu, Xin; Yang, Guangfu; Liu, Deli; Yang, Shao; Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling, Journal of Chemical Information and Modeling, 2008, 48(9), 1802.

(25) Zhang, Qing-Ye; Liu, Kai; Cui, Guzhen; Lin, Xiang Y.; Wan, Jian; Liu, De I.; Interactions of ligands with Class-II HMG-CoA reductase of Streptococcus pneumoniae by homology modeling and molecular dynamic simulations, Journal of Computational and Theoretical Nanoscience, 2007, 4(7-8), 1351.

(26) Zhang, Qing-Ye; Wan, Jian; Xu, Xin; Yang, Guang F.; Ren, Yan L.; Liu, Jun J.; Wang, Hui; Guo, Yu; Structure-based rational quest for potential novel inhibitors of human HMG-CoA reductase by combining CoMFA 3D QSAR modeling and virtual screening, Journal of Combinatorial Chemistry, 2007, 9(1), 131.

备注

获奖情况：

2013年华中农业大学第十一届青年教师讲课竞赛二等奖

2015年校级教学质量优秀奖二等奖

2015年院级教学质量优秀奖一等奖

2015年度院教学贡献奖

2017年度院教学贡献奖

2019年院级优秀班主任