报告题目：RNA-Chromatin Interactome Reveals ncRNA Functions for Transcription Regulation in 3D Genome Organization

报告人： 郑梅珍 高级科学家

报告时间：2017年3月22日（周三）10:00

报告地点：逸夫楼C座314会议室

摘要：

Noncoding RNAs (ncRNAs) are an emerging class of regulatory molecules with a broad range of regulatory functions believed to involve their interactions with chromatin. We devised an unbiased strategy to identify all RNA Interactions with Chromatin by Paired-End-Taging (RICh-PET) and applied this approach to characterize the Drosophila RNA-chromatin interactome. We discovered that many ncRNAs primarily target promoters and enhancers in open chromatin regions and co-localize with RNAPII and other TFs in a combinatorial manner. Enzymatic nuclear digestion of RNAs followed by examination of specific chromatin loci suggests that ncRNAs may collectively assist in maintaining chromatin accessability, RNAPII-mediated chromatin interactions, and the overall 3D-genome organization.

报告人简介：

郑梅珍，博士， 美国杰克逊基因组研究中心，高级科学家，在阮一骏教授团队中从事3D基因组技术研发工作。

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