龚静

姓名

龚静

性别

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职称

教授

学位

博士

电话


邮箱

gong.jing@mail.hzau.edu.cn

工作单位

华中农业大学信息学院

研究方向

  • 遗传变异的功能预测和实验验证。系统分析了人类中遗传变异对miRNA、lncRNA、甲基化、基因表达、可变剪切等功能的影响。构建了一系列遗传变异相关的数据库(miRNASNP、lncRNASNP、PancanQTL、Pancan-meQTL、SplicingQTL)。并结合分子流行病学、分子生物学等技术鉴定及验证了多个癌症相关的易感位点及基因。

  • 生物大数据的整合分析及挖掘。高通量测序数据分析及TCGA、ENCODE、GTEx等大型数据库资源的整合分析。

教育经历

2003.09-2008.06 华中科技大学,预防医学系,医学学士

2008.09-2013.06 华中科技大学,生物信息学系,工学博士

主要职历

2013.07-2015.06 华中科技大学,公共卫生学院,博士后

2015.07-2017.12 华中科技大学,公共卫生学院,讲师

2018.01-2018.09 华中科技大学,公共卫生学院,副教授,硕士生导师

2016.04-2018.04 美国,德克萨斯大学休斯顿健康科学中心(UThealth),访问学者

2018.09-至今 华中农业大学,信息学院,研究员,博士生导师

科研成果

主要致力于生物大数据的整合分析和肿瘤相关的分子流行病学研究。主持国家自然科学青年基金、中国博士后基金等课题。以第一作者或通讯作者在Annals of oncology、Nucleic Acids Research(4篇)、Cell Reports、Carcinogenesis、European journal of cancer等杂志上发表SCI文章20多篇,累计影响因子超过100分,其中2篇论文被评为ESI高被引论文,1篇引用次数达250次。

代表性论文:

1.Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X. and Han, L. (2018) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic Acids Res. (IF:10.2)

2.Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs6983267. Annals of oncology. 29(3), 632-639. (IF: 11.8)

3.Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981.(IF: 8.3,2017.11.14 Volume 21, Issue 7,封面文章)

4.Gong, J.,Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research.46, D971-D976. (IF:10.2)

5.Gong, J.,Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84. (IF:10.2)

6.Gong, J.,Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186. (IF:10.2,引用70次,ESI高被引论文)

7.Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263. (IF:4.6,引用255)

8.Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhong, R., Chang, J.,Gong, J.,* and Miao, X.* (2018) Integrative eQTL-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer. 93, 1-9. (IF:6.0)

9.Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. andGong, J*.(2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021.(IF:4.2)

10.Gong, J.,Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451. (IF:5.1,ESI高被引论文)

11.Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. andGong, J.*(2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194.(IF:4.3)

12.Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R.,Gong, J.*and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207.(IF:5.2)

13.Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. andGong, J.*(2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e0138478.(IF:2.8)

14.Gong, J.,Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029.(IF:3.3)

15.Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L.,Gong, J.*and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480.(IF:4.3)

16.Gong, J.,Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385.(IF:3.9)

17.Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306. (IF:3.7)

18.Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B.,Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.

19.Liu, D.,Gong, J.#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146. (IF:2.8)

20.龚静,柳纯洁,缪小平,郭安源.人类长链非编码RNA相关SNP鉴定与功能预测的研究进展[J].生物技术通报,2015,11:1-8.

备注

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