姓名 |
李国亮 |
性别 |
男 |
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职称 |
教授 |
学位 |
博士 |
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电话 |
027-87285078 |
邮箱 |
guoliang.li@mail.hzau.edu.cn |
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政治面貌 |
中共党员 |
工作单位 |
华中农业大学信息学院 |
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研究方向 |
三维基因组学，计算生物学，生物信息学，新一代DNA序列数据分析 |
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教育经历 |
1990.9－1994.7 西安交通大学 自动控制专业 学士 1998.9－2001.6 中科院自动化所 自动控制专业 硕士 2001.7－2002.6 新加坡－麻省理工学院学术联盟 计算机专业 硕士 2003.1－2009.7 新加坡国立大学计算学院 |
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主要职历 |
1994.7－1998.8 西安六一八研究所 助理工程师 2002.8－2005.3 新加坡国立大学计算学院 研究助理(Research Assistant) 2008.1－2008.12 新加坡国立大学计算学院 助教(Teaching Assistant) 2009.1－2012.3 新加坡基因组研究院 博士后(Post-Doctoral Fellow) 2012.4－2012.12 新加坡基因组研究院 副研究员(Research Associate) 2013.1－2013.12 美国杰克逊实验室 研究科学家(Research Scientist) 2013至今 华中农业大学教授 2013.12－2014.6 华中农业大学生命科学技术学院 教授，博导 2014.7至今 华中农业大学信息学院 生物信息系主任，教授，博导 |
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科研成果 |
本课题组长期招聘各级研究人员，包括科研助理、博士生、博士后、副研究员、研究员。有从事教学工作意向的人员，也可以和我联系。 代表性论文 1. Qiangwei Zhou; Pengpeng Guan; Zhixian Zhu; Sheng Cheng; Cong Zhou; Huanhuan Wang; Qian Xu; Wing-kin Sung; Guoliang Li, ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms, Nucleic Acids Research, October 19, 2021, 数据库链接：https://www.dna-asmdb.com 2. Liang Xie, Minghao Liu, Lun Zhao, Kai Cao, Peng Wang, Wenhao Xu, Wing-Kin Sung, Xingwang Li* & Guoliang Li*, RiceENCODE: a comprehensive epigenomic database as rice Encyclopedia of DNA Elements, Molecular Plant, 2021, 14(10):1604-1606. doi: 10.1016/j.molp.2021.08.018. Epub 2021 Aug 27. PMID: 34455096. 数据库链接：http://glab.hzau.edu.cn/RiceENCODE/ 3. Zhang, Zhengfeng*#; Xu, Yao#; Yang, Fei; Xiao, Benze; Li, Guoliang*, RiceLncPedia: a comprehensive database of rice long non-coding RNAs, Plant Biotechnology Journal, 2021 数据库链接：http://glab.hzau.edu.cn/RiceENCODE/ 4. Ke Xiao#, Dan Xiong#, Gong Chen; Jinsong Yu; Yue Li; Kening Chen; Lu Zhang; Yangyang Xu; Qian Xu; Xi Huang; Anran Gao; Kai Cao; Keji Yan; Jinxia Dai; Xueying Hu; Yijun Ruan; Zhenfang Fu*; Guoliang Li*, Gang Cao*, RUNX1-mediated alphaherpesvirus-host trans-species chromatin interaction promotes viral transcription, Science Advances, 2021 5. Wang, Yunlong; Liu, Yaqi; Xu, Qian; Xu, Yao; Cao, Kai; Deng, Nan; Wang, Ruimin; Zhang, Xueying; Zheng, Ruiqin; Guoliang Li*, Yaping Fang*, (2021). TAD boundary and strength prediction by integrating sequence and epigenetic profile information, Briefings in Bioinformatics, 2021 6. Qing Zhang#, Pengpeng Guan#, Lun Zhao#, Meng Ma, Liang Xie, Yue li, Ruiqin Zheng, Weizhi Ouyang, Shunyao Wang, Hongmeijuan Li, Ying Zhang, Yong Peng, Zhilin Cao, Wei Zhang, Qin Xiao, Yuanling Xiao, Tingdong Fu, Guoliang Li*, Xingwang Li*, Jinxiong Shen*, Asymmetric epigenome maps of subgenomes reveal imbalanced transcription and distinct evolutionary trends in Brassica napus, Molecular Plant, DOI:https://doi.org/10.1016/j.molp.2020.12.020 (IF=12.084) 7. Weizhi Ouyang#, Dan Xiong#, Guoliang Li*, Xingwang Li*, Unraveling the 3D Genome Architecture in Plants: Present and Future, Mol Plant, 2020 Dec 7;13(12):1676-1693. doi: 10.1016/j.molp.2020.10.002. (IF=12.084) 8. Qiangwei Zhou, Ze Wang, Jing Li, Wing-Kin Sung, Guolaing Li*, MethHaplo: combining allele-specific DNA methylation and SNPs for haplotype region identification, BMC Bioinformatics, Oct 2020, 21, Article number: 451 (2020) 9. Cao, Canhui; Xu, Qian; Lin, Shitong; Zhi, Wenhua; Lazare, Cordelle; Meng, Yifan; Wu, Ping; Gao, Peipei; Li, Kezhen; Wei, Juncheng; Wu, Peng*; Li, Guoliang*, Mapping long-range contacts between risk loci and target genes in human diseases with Capture Hi-C, Clinical and Translational Medicine, 2020, 10(5): e183 (IF=7.919) 10. Cao, Canhui#; Hong, Ping#; Huang, Xingyu#; Lin, Da; Cao, Gang; Wang, Liming; Feng, Bei; Wu, Ping; Shen, Hui; Xu, Qian; Ren, Ci; Meng, Yifan; Zhi, Wenhua; Yu, Ruidi; Wei, Juncheng; Ding, Wencheng; Tian, Xun; Zhang, Qinghua; Li, Wei; Gao, Qinglei; Chen, Gang; Li, Kezhen; Sung, Wing-Kin; Hu, Zheng*; Wang, Hui*; Guoliang Li*, Peng Wu*, HPV-CCDC106 Integration Alters Local Chromosome Architecture and Hijacks an Enhancer by Remodeling the 3D Genome Structure in Cervical Cancer, JGG, (2020), https://doi.org/10.1016/j.jgg.2020.05.006 11. Yan Zhang, Guoliang Li*, Advances in Technologies for 3D Genomics Research, SCIENCE CHINA Life Sciences, 63, 811–824, https://doi.org/10.1007/s11427-019-1704-2 (2020) 12. Lun Zhao#, Liang Xie#, Qing Zhang#, Weizhi Ouyang, Li Deng, Pengpeng Guan, Meng Ma, Yue Li, Ying Zhang, Qin Xiao, Jingwen Zhang, Hongmeijuan Li, Shunyao Wang, Jiangwei Man, Zhilin Cao, Qinghua Zhang, Qifa Zhang, Guoliang Li*, Xingwang Li*, Integrative analysis of reference epigenomes in 20 rice varieties, Nature Communications, volume 11, 2658 (2020) https://doi.org/10.1038/s41467-020-16457-5 (IF=12.121) 13. Hui Zhang, Ruiqin Zheng, Yunlong Wang, Yu Zhang, Ping Hong, Yaping Fang, Guoliang Li*, Yuda Fang*, The effects of Arabidopsis genome duplication on the chromatin organization and transcriptional regulation, Nucleic Acids Research, 47(15), 7857–7869, DOI: 10.1093/nar/gkz511 (2019) 14. Lun Zhao#, Shuangqi Wang#, Zhilin Cao#, Weizhi Ouyang, Qing Zhang, Liang Xie, Ruiqin Zheng, Minrong Guo, Meng Ma, Zhe Hu, Wing-Kin Sung, Qifa Zhang, Guoliang Li* & Xingwang Li*, Chromatin loops associated with active genes and heterochromatin shape rice genome architecture for transcriptional regulation, Nature Communications, 10, 3640, DOI: 10.1038/s41467-019-11535-9, (2019) 15. Yong Peng#, Dan Xiong#, Lun Zhao, Weizhi Ouyang, Shuangqi Wang, Jun Sun, Qing Zhang, Pengpeng Guan, Liang Xie, Wenqiang Li, Guoliang Li*, Jianbing Yan*, Xingwang Li*, Chromatin Interaction Maps Reveal Genetic Regulation for Quantitative Traits in Maize, Nature Communications, 10, 2632, DOI: 10.1038/s41467-019-10602-5, (2019) 16. Qiangwei Zhou, Jing-Quan Lim, Wing-Kin Sung*, Guoliang Li*, An Integrated Package for Bisulfite DNA Methylation Data Analysis with Indel-sensitive Mapping, BMC Bioinformatics, 2019, 20:47, DOI: 10.1186/s12859-018-2593-4 (22 January 2019) 17. Da Lin#, Ping Hong#, Liang Li, Siheng Zhang, Weize Xu, Muhammad Jamal, Keji Yan, Yingying Lei, Yijun Ruan, Zhenfang Fu, Guoliang Li* & Gang Cao*, Digestion-Ligation-Only Hi-C, a Simple, Cost-effective, and Highly Efficient Method for Chromosome Conformation Capture, Nature Genetics, volume 50, pages 754–763, doi:10.1038/s41588-018-0111-2 (2018) 18. Guoliang Li#, Xiaoan Ruan#, Raymond K. Auerbach#, Kuljeet Singh Sandhu#, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang, Hui Shan Sim, Su Qin Peh, Fabianus Hendriyan Mulawadi, Chin Thing Ong, Yuriy L. Orlov, Shuzhen Hong, Zhizhuo Zhang, Steve Landt, Debasish Raha, Ghia Euskirchen, Chia-Lin Wei, Weihong Ge, Huaien Wang, Carrie Davis, Katherine I. Fisher-Aylor, Ali Mortazavi, Mark Gerstein, Thomas Gingeras, Barbara Wold, Yi Sun, Melissa J. Fullwood, Edwin Cheung, Edison Liu, Wing-Kin Sung, Michael Snyder, and Yijun Ruan, Extensive Promoter-centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation, Cell, 148, 84-98 (# These authors contributed equally) 19. Lusy Handoko#, Han Xu#, Guoliang Li#, Chew Yee Ngan, Elaine Chew, Marie Schnapp, Charlie Wah Heng Lee, Chaopeng Ye, Joanne Lim Hui Ping, Fabianus Mulawadi, Eleanor Wong, Jianpeng Sheng, Yubo Zhang, Thompson Poh, Chee Seng Chan, Galih Kunarso, Atif Shahab, Guillaume Bourque, Valere Cacheux-Ratabou, Wing-Kin Sung, Yijun Ruan, Chia-Lin Wei, CTCF-Mediated Functional Chromatin Interactome in Pluripotent Cells, Nature Genetics 43, 630-638. (# These authors contributed equally) 20. Li Yuqing, Li Yi, Wedren S, Guoliang Li, Charn TH, Vasant DK, Bonnard C, Czene K, Humphreys K, Darabi H, Einarsdttir K et al: Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor positive breast cancer. Breast Cancer Research 2011, 13(1):R10. 21. Say Li Kong#, Guoliang Li#, Siang Lin Loh, Wing-Kin Sung, Edison T. Liu, Cellular reprogramming by the conjoint action of ERα, FOXA1 and GATA3 for ligand inducible growth. Molecular Systems Biology 2011, 7:526 (# These authors contributed equally) 22. Guoliang Li#, M.J. Fullwood#, H. Xu#, F.H. Mulawadi, S. Velkov, V. Vega, P.N. Ariyaratne, Y.B. Mohamed, H.-S. Ooi, C. Tennakoon, C.-L. Wei, Y. Ruan, W.-K. Sung, ChIA-PET tool for comprehensive chromatin interaction analysis with paired-end tag sequencing, Genome Biology 11 (2) (2010) R22, DOI: 10.1186/gb-2010-1111-1182-r1122 (# These authors contributed equally to the work). 23. Guoliang Li, Steel Mike, Louxin Zhang, More Taxa Are Not Necessarily Better For the Reconstruction of Ancestral Character States, Systematic Biology 57 (4) (2008) 647-653. 24. Guoliang Li, Tze-Yun Leong, and Louxin Zhang, Translation Initiation Sites Prediction with Mixture Gaussian Models in Human cDNA Sequences. IEEE Transactions on Knowledge and Data Engineering, 2005. 17(8): p. 1152-1160. ) 专利 1. 谭民;景奉水;梁自泽;李国亮;王跃：开放式工业机器人控制平台，中国实用新型专利，专利公开号：CN2447131, 公开时间：2001.09.12 2. 谭民;梁自泽;李国亮;景奉水;王跃：开放式工业机器人视觉控制平台，中国实用新型专利，专利公开号：CN2510250, 公开时间：2002.09.11 3. 谭民;景奉水;梁自泽;李国亮;王跃：开放式工业机器人控制平台，中国发明专利，专利公开号： CN1344600, 公开时间：2002.04.17 4. 谭民;梁自泽;李国亮;景奉水：开放式工业机器人视觉控制平台，中国发明专利，专利公开号：CN1417006, 公开时间：2003.05.14 |
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备注 |
本课题组长期招聘各级研究人员，包括科研助理、博士生、博士后、副研究员、研究员。有从事教学工作意向的人员，也可以和我联系。 获奖经历 1999 中国科学院优秀研究生奖学金 2001~2002 新加坡-麻省理工学院学术联盟奖学金 2004/2005 新加坡国立大学计算学院，院长奖学金 2005~2007 新加坡国立大学计算学院，研究奖学金 2005/2006 新加坡国立大学，校长奖学金 2006/2007 新加坡国立大学，校长奖学金 2018 华中农业大学，第6届师德先进个人 2020 湖北省委高校工委，优秀共产党员 |
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