郑金水 【副教授】
姓名 郑金水 性别
职称 副教授 学位 博士
电话 027-87283455 邮箱 jszheng@mail.hzau.edu.cn
工作单位 华中农业大学信息学院
研究方向 基因组学,植物保护
教育经历 2013年9月~ 2013年12月,加拿大阿尔伯特大学,访问研究生
2006年9月~ 2014年6月,华中农业大学,微生物学,硕、博士
2002年9月~ 2006年6月,武汉理工大学,生物技术,学士

主要职历 2018年1月至今,华中农业大学信息学院,副教授,硕/博导
2016年7月~2017年12月,华中农业大学信息学院,副教授,硕导
2014年7月~ 2016年6月,华中农业大学,植物保护,博士后

学术兼职:
2016年至今,Frontiers in Microbiology,Review Editor
科研成果

研究方向为农业微生物基因组学与微生物组学,具体对象涉及到杀虫微生物、植物病原细菌与病原线虫、土壤微生物组与植物微生物组等。结合使用实验生物学和生物信息学等手段,尝试解决植物病虫害防治相关的科学问题,主要涉及新型细菌生防资源的挖掘,植物病原线虫与细菌的基于群体遗传学的致病机理,以及从生态学的角度防控植物地下病虫害等。

 

主持的科研项目:

1. 国家自然科学基金面上项目,苏云金芽胞杆菌H-血清型决定的遗传基础研究,2018-2021

2. 国家自然科学基金青年基金,基于基因组学的苏云金芽胞杆菌资源的多样性研究,2016-2018

3. 博士后基金面上项目,具有高效杀虫活性的苏云金芽胞杆菌的比较基因组学研究,2015-2016

4. 博士后基金特别资助,我国不同地域的苏云金芽胞杆菌的基因组资源多样性研究,2016-2017

 

参与的科研项目:

1. 国家自然科学基金面上项目,嗜热古菌I-ACRISPR-Cas系统原发适应的分子机制

2. 国家自然科学基金面上项目,苏云金芽胞杆菌杀虫增效天然产物Zwittermicin A生物合成中的重要调控因子及其作用方式

3. 国家自然科学基金面上项目,苏云金芽胞杆菌控制溶源性噬菌体关键因子的功能和作用模式

4. 国家自然科学基金面上项目,苏云金芽胞杆菌杀虫晶体蛋白Cry5Ba表达沉默的负调控因子及其调控模式

5. 国家自然科学基金青年基金,苏云金芽胞杆菌溶源性噬菌体裂解关键控制因子

6. 国家自然科学基金面上项目,苏云金芽胞杆菌中晶胞粘连的形成模式         

7. 国家863计划,细菌类生物杀虫剂研究和产品创制

8. 农业部948 重点项目,高效新型微生物资源引进与创新

 

发表SCI论文:

1. Zheng J, Gao Q, Liu L, Liu H, Wang Y, Peng D, Ruan L, Raymond B, Sun M*. 2017. Comparative Genomics of Bacillus thuringiensis Reveals a Path to Specialized Exploitation of Multiple Invertebrate Hosts. mBio 8 (4):e00822-17.

2. Zheng J, Peng D, Chen L, Liu H, Chen F, Xu M, Ju S, Ruan L, Sun M*. 2016. The Ditylenchus destructor genome provides new insights into the evolution of plant parasitic nematodes. Proc Biol Sci 283(1835): 20160942.

3. Zheng J, Ruan L, Sun M, Ganzle M*. 2015. A Genomic View of Lactobacilli and Pediococci Demonstrates that Phylogeny Matches Ecology and Physiology. Appl Environ Microbiol 81:7233-43.

4. Zheng J, Guan Z, Cao S, Peng D, Ruan L, Jiang D, Sun M*. 2015. Plasmids are vectors for redundant chromosomal genes in the Bacillus cereus group. BMC Genomics 16:6.

5. Zheng J, Ganzle MG, Lin XB, Ruan L, Sun M*. 2015. Diversity and dynamics of bacteriocins from human microbiome. Environ Microbiol 17:2133-43.

6. Zheng J#, Zhao X#, Lin XB, Gänzle MG*. 2015. Comparative genomics Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations. Sci Rep 5, 18234.

7. Zheng J, Peng D, Song X, Ruan L, Mahillon J, Sun M*. 2013. Differentiation of Bacillus anthracis, B. cereus, and B. thuringiensis on the basis of the csaB gene reflects host source. Appl Environ Microbiol 79:3860-3.

8. Zheng J, Peng D, Ruan L, Sun M*. 2013. Evolution and dynamics of megaplasmids with genome sizes larger than 100 kb in the Bacillus cereus group. BMC Evol Biol 13:262.

9. Duar RM, Lin XB, Zheng J, Martino ME, Grenier T, Perez-Munoz ME, Leulier F, Ganzle M, Walter J*. 2017. Lifestyles in transition: evolution and natural history of the genus Lactobacillus. FEMS Microbiol Rev 41:S27-S48.

10. Peng D, Luo X, Zhang N, Guo S, Zheng J, Chen L, Sun M*. 2018. Small RNA-mediated Cry toxin silencing allows Bacillus thuringiensis to evade Caenorhabditis elegans avoidance behavioral defenses. Nucleic Acids Res 46:159-173.

11. Zheng Z, Zheng J, Peng D, Sun M*. 2017. Complete genome sequence of Fictibacillus arsenicus G25-54, a strain with toxicity to nematodes. J Biotechnol 241:98-100.

12. Geng C, Liu Y, Li M, Tang Z, Muhammad S, Zheng J, Wan D, Peng D, Ruan L, Sun M*. 2017. Dissimilar Crystal Proteins Cry5Ca1 and Cry5Da1 Synergistically Act against Meloidogyne incognita and Delay Cry5Ba-Based Nematode Resistance. Appl Environ Microbiol 83(18): e03505-16.

13. Zheng Z, Zheng J, Zhang Z, Peng D, Sun M*. 2016. Nematicidal spore-forming Bacilli share similar virulence factors and mechanisms. Sci Rep 6:31341.

14. Zheng Z, Zheng J, Liu H, Peng D, Sun M*. 2016. Complete genome sequence of Fictibacillus phosphorivorans G25-29, a strain toxic to nematodes. J Biotechnol 239:20-22.

15. Xin B, Zheng J, Liu H, Li J, Ruan L, Peng D, Sajid M, Sun M*. 2016. Thusin, a Novel Two-Component Lantibiotic with Potent Antimicrobial Activity against Several Gram-Positive Pathogens. Front Microbiol 7:1115.

16. Wang Y, Fu J, Zhu Q, Zhu L, Zheng J, Liu H, Peng D, Ruan L, Sun M*. 2016. Complete genome sequence of Bacillus thuringiensis serovar alesti BGSC 4C1, a typical strain with toxicity to Lepidoptera insects. J Biotechnol 239:61-64.

17. Peng D, Lin J, Huang Q, Zheng W, Liu G, Zheng J, Zhu L, Sun M*. 2016. A novel metalloproteinase virulence factor is involved in Bacillus thuringiensis pathogenesis in nematodes and insects. Environ Microbiol 18:846-62.

18. Ju S, Zheng J, Lin J, Geng C, Zhu L, Guan Z, Zheng Z, Sun M*. 2016. The complete genome sequence of Alcaligenes faecalis ZD02, a novel potential bionematocide. J Biotechnol 218:73-4.

19. Ju S, Lin J, Zheng J, Wang S, Zhou H, Sun M*. 2016. Alcaligenes faecalis ZD02, a Novel Nematicidal Bacterium with an Extracellular Serine Protease Virulence Factor. Appl Environ Microbiol 82:2112-20.

20. Dong Z, Li J, Zheng J, Geng C, Peng D, Sun M*. 2016. Complete genome sequence of Bacillus thuringiensis CTC-A typical strain with high production of S-layer proteins. J Biotechnol 220:100-1.

21. Zhu L, Tian LJ, Zheng J, Gao QL, Wang YY, Peng DH, Ruan LF, Sun M*. 2015. Complete genome sequence of Bacillus thuringiensis serovar galleriae strain HD-29, a typical strain of commercial biopesticide. J Biotechnol 195:108-9.

22. Zhu L, Peng D, Wang Y, Ye W, Zheng J, Zhao C, Han D, Geng C, Ruan L, He J, Yu Z, Sun M*. 2015. Genomic and transcriptomic insights into the efficient entomopathogenicity of Bacillus thuringiensis. Sci Rep 5:14129.

23. Xin B, Zheng J, Xu Z, Song X, Ruan L, Peng D, Sun M*. 2015. The Bacillus cereus group is an excellent reservoir of novel lanthipeptides. Appl Environ Microbiol 81:1765-74.

24. Xin B, Zheng J, Xu Z, Li C, Ruan L, Peng D, Sun M*. 2015. Three Novel Lantibiotics, Ticins A1, A3, and A4, Have Extremely Stable Properties and Are Promising Food Biopreservatives. Appl Environ Microbiol 81:6964-72.

25. Ruan L, Wang H, Cai G, Peng D, Zhou H, Zheng J, Zhu L, Wang X, Yu H, Li S, Geng C, Sun M*. 2015. A two-domain protein triggers heat shock pathway and necrosis pathway both in model plant and nematode. Environ Microbiol 17:4547-65.

26. Peng DH, Pang CY, Wu H, Huang Q, Zheng JS, Sun M*. 2015. The expression and crystallization of Cry65Aa require two C-termini, revealing a novel evolutionary strategy of Bacillus thuringiensis Cry proteins. Sci Rep 5:8291.

27. Mercer RG, Zheng J, Garcia-Hernandez R, Ruan L, Ganzle MG, McMullen LM. 2015. Genetic determinants of heat resistance in Escherichia coli. Front Microbiol 6:932.

28. Ianniello RG, Zheng J, Zotta T, Ricciardi A, Ganzle MG. 2015. Biochemical analysis of respiratory metabolism in the heterofermentative Lactobacillus spicheri and Lactobacillus reuteri. J Appl Microbiol 119:763-75.

29. Gao Q, Zheng J, Zhu L, Ruan L, Peng D, Sun M*. 2015. Complete genome sequence of Bacillus thuringiensis tenebrionis 4AA1, a typical strain with toxicity to Coleopteran insects. J Biotechnol 204:15-6.

30. Wang P, Zhang C, Guo M, Guo S, Zhu Y, Zheng J, Zhu L, Ruan L, Peng D, Sun M*. 2014. Complete genome sequence of Bacillus thuringiensis YBT-1518, a typical strain with high toxicity to nematodes. J Biotechnol 171:1-2.

31. Liu Y, Ye W, Zheng J, Fang L, Peng D, Ruan L, Sun M*. 2014. High-quality draft genome sequence of nematocidal Bacillus thuringiensis Sbt003. Stand Genomic Sci 9:624-31.

32. Geng C, Tang Z, Peng D, Shao Z, Zhu L, Zheng J, Wang H, Ruan L, Sun M*. 2014. Draft genome sequence of Bacillus firmus DS1. J Biotechnol 177:20-1.

33. Luo X, Chen L, Huang Q, Zheng J, Zhou W, Peng D, Ruan L, Sun M*. 2013. Bacillus thuringiensis metalloproteinase Bmp1 functions as a nematicidal virulence factor. Appl Environ Microbiol 79:460-8.

34. Zhu Y, Shang H, Zhu Q, Ji F, Wang P, Fu J, Deng Y, Xu C, Ye W, Zheng J, Zhu L, Ruan L, Peng D, Sun M*. 2011. Complete genome sequence of Bacillus thuringiensis serovar finitimus strain YBT-020. J Bacteriol 193:2379-80.

35. Zhou Z, Peng D, Zheng J, Guo G, Tian L, Yu Z, Sun M*. 2011. Two groups of S-layer proteins, SLP1s and SLP2s, in Bacillus thuringiensis co-exist in the S-layer and in parasporal inclusions. BMB Rep 44:323-8.

36. Deng Y, Zhu Y, Wang P, Zhu L, Zheng J, Li R, Ruan L, Peng D, Sun M*. 2011. Complete genome sequence of Bacillus subtilis BSn5, an endophytic bacterium of Amorphophallus konjac with antimicrobial activity for the plant pathogen Erwinia carotovora subsp. carotovora. J Bacteriol 193:2070-1.

37. Liu XY, Ruan LF, Hu ZF, Peng DH, Cao SY, Yu ZN, Liu Y, Zheng JS, Sun M*. 2010. Genome-wide screening reveals the genetic determinants of an antibiotic insecticide in Bacillus thuringiensis. J Biol Chem 285:39191-200.

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