张青叶 【副教授】
姓名 张青叶 性别
职称 副教授 学位 博士
电话 027-87280877 邮箱 zqy@mail.hzau.edu.cn
工作单位 华中农业大学信息学院
研究方向 蛋白质结构分析及药物发现研究
教育经历

2003/09-2008/06,华中师范大学,化学学院,硕博连读
     1999/09-2003/07,安庆师范学院,化学系,本科

主要职历

2014/07- 至今     华中农业大学,信息学院,副教授
     2011/01-2014/06,华中农业大学,理学院,副教授
     2010/10-2010/12,华中农业大学,理学院,讲师
     2008/07-2010/09,华中农业大学,生命科学技术学院,博士后

科研成果

近年主持的科研项目:

1、博士后一等资助,项目名称: 苏云金芽胞杆菌YBT-1520的代谢网络调控研究,起止年限:2008.08-2010.09

2、博士后特别资助,项目名称:基于Glmu靶酶结构的新型抑制剂先导化合物的合理设计与筛选,起止年限:2009.10-2011.06

3、国家自然科学基金,项目名称:GlmU靶酶活性中心与其配体相互作用的机理及其抑制剂先导结构的研究,起止年限:2010.01-2012.12

4、华中农业大学培育专项,项目名称:基于靶酶结构的新型抑制剂结构的优化设计与合成,起止年限:2011.05-2012.12

 

近年发表的文章: 

1、Jingnan Jin, Xiaojuan Qi, Dandan Yao, Bangqiang Mao, Jianhong Li, Qing Y. Zhang* and Changshui Chen*. Rational Design and Screening Study of Novel Lead Compound Based on Acetohydroxyacid Synthase Structure. Chem Biol Drug Des, 86, 316-324, 2014(IF: 2.469)

2、Xia-Li Yue  Hu Li  Shuang-Shuang Liu  Qing Y. Zhang*  Jing-Jing Yao  Fei-Yan Wang. N-Fluorinated phenyl-N-pyrimidyl urea derivatives: Synthesis, biological evaluation and 3D-QSAR study. Chinese Chemical Letters. 25, 1069-1072, 2014. (IF: 1.178)

3、Jing Wang1Qing Y. Zhang1, Zongqing Huang, Ziduo Liu Directed evolution of a family 26 glycoside hydrolase: Endo- b -1,4-mannanase from Pantoea agglomerans A021. J of Biotechnology 167, 350-356, 2013(IF: 3.183, the first two authors contributed equally)

4、Jun Min, Da Lin, Qing Y. Zhang*, Jibing Zhang, Ziniu Yu. Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU. Eur. J. Med. Chem. 53, 150-158, 2012. (IF: 3.499)

5、Jingnan Jin, Hongju Ma, Xiufang Cao, Shengzhen Xu, Jianhong Li, Qing Y. Zhang*, Changshui Chen. The discovery of the novel lead compound of N-nitroureas target on acetohydroxyacid synthase. Pestic. Biochem. Phys. 104, 218-223, 2012(IF: 2.111)

6、Qing Y. Zhang, Chan Yu, Jun Min, Yan Wang, Jin He, Ziniu Yu*. Rational Questing for Potential Novel Inhibitors of FabK from Streptococcus pneumoniae by Combining FMO Calculation, CoMFA 3D-QSAR Modeling and Virtual Screening.J. Mol. Model17, 1483-1492, 2011(IF: 1.871)

7、Jun Min, Xiaoli Zhang, Lei Wang, Xia Zou, Qing Y. Zhang*, Jin He*. Mutational analysis of the interaction between a potential inhibitor luteolin and enoyl-ACP reductase (FabI) from Salmonella enterica. J. Mol. Catal b-Enzym. 68, 174-180, 2011. (IF: 2.330)

8、Qing Y. Zhang, Ding Li, Yangliang Ren, Jie Zhang, Jian Wan, Pei Wei, Zhigang Chen, Deli Liu, Ziniu Yu. Structure-based Rational Screening of Novel Hit Compounds with Structural Diversity for Cytochrome P450 Sterol 14a-demethylase from Penicillium digitatumJ. Chem. Inf. Model. 50, 317-325, 2010. (IF: 3.822)

9、Jingjing Yao1Qing Y. Zhang1, Jun Min, Jin He*, Ziniu Yu*. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Bioorg. Med. Chem. Lett. 20, 56-59, 2010. (IF: 2.661,the first two authors contributed equally)

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