孔德信 【教授】
姓名 孔德信 性别
职称 教授 学位 博士
电话 15827601178 邮箱 dxkong@163.com
工作单位 华中农业大学信息学院
研究方向 化学信息学、分子模拟、药物设计
教育经历

博士    中国海洋大学海洋药物与食品研究所,2002.9-2005.7
     硕士    山东师范大学化学系    专业:物理化学, 1999.9-2002.7
     本科    山东师范大学化学系    专业:应用化学, 1995.9-1999.7

主要职历

访学    国际科学与高技术中心(ICS-UNIDO),2009.5.1-11.30    
     副教授  华中农业大学生命科学与技术学院, 2009.1-
     讲师   山东理工大学生命科学学院, 2005.7-2008.12

科研成果

   A      A、科研项目

1. 国家自然科学基金面上项目:《三维生物相关谱的计算及其在药物发现中的应用》,
项目批准号:212750612013-2016,批准经费: 80万元,主持。

2. 国家自然科学基金面上项目:《生物相关谱在药物设计中的应用研究》,
项目批准号:210750462011-2013,批准经费: 35万元,主持。

3. 科技部第20届中泰国际合作交流项目:《微生物药物设计合作互访》,
项目批准号:20-410C2013.8,主持。

4. 国家自然科学基金:《基于胡萝卜软腐欧文氏菌基因组信息的农用杀菌活性化合物筛选》,
项目批准号:310716592011-2013,批准经费:37万元,第二。

5. 国家自然科学基金:《胡萝卜软腐欧文氏菌功能基因分析及药物靶点初筛》,
项目批准号:306001192007,批准经费:8万元,第三。

6. 湖北省自然科学基金创新群体:《基于组学的新药发现技术》
项目批准号:2013CFA0162014-2016,批准经费:40万,第四。

7. 863子课题:《昆虫生长调节剂靶标创新开发与应用》
项目编号:2011AA10A2042011-2015,参与。


            B. 代表性论文

  1. Bin Zhou, Rong Wang, Ping Wu, De-Xin Kong*. Drug repurposing based on drug-drug interaction data. Chem Bio Drug Design. 2014, (IF~2.47, Accepted)
  2. Zhi-Luo Deng, Cai-Xia Du, Xiao Li, Ben Hu, Zheng-Kun Kuang, Rong Wang, Shi-Yu Feng, Hong-Yu Zhang, De-Xin Kong*. Exploring the biologically relevant chemical space for drug discovery. J. Chem. Info. Model., 2013, 53: 2820-2828. (IF=4.304)
  3. Jiang Ying-Ying1Kong De-Xin1, Qin Tao, Li Xiao, Caetano-Anollés Gustavo, Zhang Hong-Yu. The Impact of Oxygen on Metabolic Evolution: a Chemoinformatic Investigation. Plos Comp. Biol. 2012, 8:e1002426. (IF~6.23, the first two authors contributed equally.)
  4. Kong De-Xin, Jiang Ying-Ying, Zhang Hong-Yu. Marine natural products as sources of novel scaffolds: achievement and concernDrug Discov. Today, 2010, 15:884-886.
  5. Kong De-Xin, Ren Wei, Lu Wei, Zhang Hong-Yu. Do Biologically Relevant Compounds Have More Chance To Be Drugs? J. Chem. Info. and Model. 2009, 49 (10): 2376-2381.
  6. Kong De-xin, Li Xue-juan, and Zhang Hong-yu. Where is the hope for drug discovery? Let history tell the future. Drug Discov. Today, 2009, 14: 115-119. (ScienceDirect Top25 Hottest Articles)
  7. Kong De-Xin, Guo Ming-Yue, Xiao Zhi-Hong, Chen Ling-Ling, and Zhang Hong-Yu. Historical Variation of Structural Novelty in Natural Product LibraryChem. Biodiv. 2011, 8: 1968-1977.
  8. Zhu Qiang, Qin Tao, Jiang Ying-Ying, Ji Cong, Kong De-Xin, Ma Bin-Guang, Zhang Hong-Yu. Chemical Basis of Metabolic Network OrganizationPlos Comp. Biol. 2011, 7: e1002214. (the first six authors contributed equally.)
  9. Cao Li-min1Kong De-xin1, Sui Jian-xin, Jiang Tao, Li Zong-yan, Ma Lei, Lin Hong. Broad-specific antibodies for generic immunoassay of quinolone: development of a molecular model for selection of haptens based on molecular filed-overlapping. Analy. Chem., 2009, 81 (9), 3246-3251. (The first two authors contributed equally.)
  10. Kong De-xin, Li Xue-juan, and Zhang Hong-yu. Convergent evolution of medicines. ChemMedChem, 2008. 3(8): 1169-71.
  11. Kong De-xin, Li Xue-juan, Tang Guang-yan, Zhang Hong-yu. How Many Traditional Chinese Medicine Components Have Been Recognized by Modern Western Medicine? A Chemoinformatic Analysis and Implications for Finding Multicomponent Drugs. ChemMedChem, 2008, 3:233-236.
  12. Yibo Jiang, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Ishwari Kadariya, Zhangrui Cheng, Yuwei Ren, Xing Chen, Ao Zhou, Liguo Yang, Dexin Kong*, and Shujun Zhang*, Analysis of the Binding Sites of Porcine Sialoadhesin Receptor with PRRSV. Int. J. Mol. Sci. 2013, 14(12), 23955-23979. (IF=2.464)

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