马彬广 【教授】
姓名 马彬广 性别
职称 教授 学位 博士
电话 027-87280877 邮箱 mbg@mail.hzau.edu.cn
工作单位 华中农业大学信息学院
研究方向 生物物理学;计算生物学;系统与合成生物学
教育经历 2004.9-2007.6, 苏州大学, 高分子化学与物理(化学生物学方向), 博士
2001.9-2004.6, 天津大学, 生物物理学, 硕士 
1997.9-2001.7, 河北工业大学, 应用物理学, 本科
主要职历 2016.12至今, 华中农业大学信息学院, 教授  博士生导师
2014.7-2016.12, 华中农业大学信息学院, 副教授
2009.11-2014.7, 华中农业大学生命科学技术学院, 副教授
2007.11-2009.11, Bergen Center for Computational Sciences, Norway(挪威), 博士后

学术兼职:
Nature旗下国际刊物Scientific Reports编委
iGEM国际遗传工程机器设计竞赛2013亚洲赛区评委
第八届国际生物信息研讨会(IBW2010-武汉)组委会程序委员
科研成果 近几年来主要在计算生物学领域从事基因组分析、蛋白质折叠及蛋白质相互作用、微生物热适应的分子机理等方向的研究工作,在Nucleic Acid Res., Structure, PLoS Comput Biol., Sci. Rep., J. Mol. Biol.,Proteins, Genome Biol., BMC Genomics, PLoS One, FEBS J., FEBS Lett., Gene, Biochem. Biophys. Res. Commun.等国际重要期刊发表SCI论文20多篇,其中,关于蛋白质折叠类型预测的JMB论文入选Faculty of 1000 Biology。本人曾受邀担任国内外重要期刊审稿人,例如:Journal of Chemical Information and Modeling, The Open Structural Biology Journal, Journal of Molecular Biology, Journal of Theoretical Biology, Molecular BioSystems, Gene, Genomics, Journal of Biomolecular Structure & Dynamics、生物物理学报等。 


发表论文:(上标1表示并列第一作者,星号* 表示通讯作者)

1. Yi Yang, Xiao-Pan Hu, Bin-Guang Ma*, Construction and simulation of the Bradyrhizobium diazoefficiens USDA110 metabolic network: a comparison between free-living and symbiotic states. Mol. BioSyst., 2017, (First published online 31 Jan 2017). http://pubs.rsc.org/en/content/articlelanding/2017/mb/c6mb00553e

2. Hong-Rui Xu, Jun-Feng Cheng, Xiao-Pan Hu, Ying-Ying Chu, Bin-Guang Ma*, Are protein hubs faster folders? Exploration based on Escherichia coli proteome. Amino Acids 2016, 48(12): 2747–2753. http://link.springer.com/article/10.1007/s00726-016-2309-x


3. 马彬广,蛋白折叠预测,科学通报 61(24), 2670-2680 (2016); doi: 10.1360/N972016-00658; (约稿综述,Science125个科学前沿问题系列解读,第58问:Can we predict how proteins will fold?)http://engine.scichina.com/doi/10.1360/N972016-00658

4. Yi-Ming He, Bin-Guang Ma*, Abundance and Temperature Dependency of Protein-Protein Interaction Revealed by Interface Structure Analysis and Stability Evolution. Sci Rep. 2016 May 25; 6:26737.  doi:10.1038/srep26737.

5. Xiao-Pan Hu, Yi Yang, Bin-Guang Ma*, Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability. Sci Rep. 2015 Jun 9; 5:11113. doi: 10.1038/srep11113.

6. Ting Xie1, Liang-Yu Fu1, Qing-Yong Yang1, Heng Xiong1, Hong-Rui Xu, Bin-Guang Ma*, Hong-Yu Zhang*, Spatial features for Escherichia coli genome organization, BMC Genomics. 2015 Feb 5;16:37. doi: 10.1186/s12864-015-1258-1.

7. Heng Xiong, Yi Yang, Xiao-Pan Hu, Yi-Ming He, Bin-Guang Ma*, Sequence determinants of prokaryotic gene expression level under heat stress. Gene 2014, 551: 92-102.

8. Shanming Wang, Baohai Hao, Jiarui Li, Huilin Gu, Jieli Peng, Fuli Xie, Xinyin Zhao, Christian Frech, Nansheng Chen*, Binguang Ma*, Youguo Li*, Whole-genome sequencing of Mesorhizobium huakuii 7653R provides molecular insights into host specificity and symbiosis island dynamics. BMC Genomics 2014, 15:440 (6 June 2014)

9. Jieli Peng, Baohai Hao, Liu Liu, Shanming Wang, Binguang Ma, Yi Yang, Fuli Xie, Youguo Li RNA-Seq and Microarrays Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells. PLoS ONE (2014) 9(4): e93626. doi:10.1371/journal.pone.0093626.

10. Alexander Goncearenco, Bin-Guang Ma, and Igor N. Berezovsky, Molecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins Nucl. Acids Res. (2014) 42 (5): 2879-2892.

11. Qiang Zhu1, Tao Qin1, Ying-Ying Jiang1, Cong Ji1, De-Xin Kong1, Bin-Guang Ma1, Hong-Yu Zhang* Chemical basis of metabolic network organization. PLoS Comput Biol. 2011 (10): e1002214.

12. Liang-Yu Fu, Guang-Zhong Wang, Bin-Guang Ma, Hong-Yu Zhang* Exploring the common molecular basis for the universal DNA mutation bias: revival of Löwdin mutation model.  Biochem Biophys Res Commun. (2011) 409: 367-371.

13. Bin-Guang Ma*, Hong-Yu Zhang* Stoichiometry and Preferential Interaction: Two Components of the Principle for Protein Structure Organization. Journal of Biomolecular Structure & Dynamics. (2011) 28: 619-20; discussion 669-674.

14. Bin-Guang Ma, Igor N. Berezovsky* The MBLOSUM: a server for deriving mutation targets and position-specific substitution rates. Journal of Biomolecular Structure & Dynamics (2010), 28, 415-419.

15. Bin-Guang Ma1, Alexander Goncearenco1, Igor N. Berezovsky* Thermophilic adaptation of protein complexes inferred from proteomic homology modeling. Structure (2010) 18, 819-828.

16. Bin-Guang Ma*, Ling-Ling Chen, Hong-Yu Zhang. FDserver: A web service for protein folding research. NaturePrecedings (2008)

17. Bin-Guang Ma* Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis. Nature Precedings (2008) .

18. Ji Wang, Bin-Guang Ma*, Hong-Yu Zhang, Ling-Ling Chen, Shi-Cui Zhang*. How does gene expression level contribute to thermophilic adaptation of prokaryotes? An exploration based on predictors. Gene (2008) 421, 32-36.

19. Bin-Guang Ma1, Lei Chen1, Hong-Fang Ji, Zhong-Hua Chen, Fu-Rong Yang, Ling Wang, Ge Qu, Ying-Ying Jiang, Cong Ji, Hong-Yu Zhang*. Characters of very ancient proteins. Biochemical & Biophysical Research Communications (2008) 366, 607-611.

20. Bin-Guang Ma*, Ling-Ling Chen, Hong-Yu Zhang*. What determines protein folding type? An investigation of intrinsic structural properties and its implications for understanding folding mechanisms. Journal of Molecular Biology (2007) 370, 439-448. 该论文入选Faculty of 1000 Biology

21. Yan Zhou1, Bin-Guang Ma1, Hong-Yu Zhang*. Human oncogene tissue-specific expression level significantly correlates with sequence compositional features. FEBS Letters (2007) 581, 4361-4365.

22. Ke Xu and Bin-Guang Ma*. Comparative analysis of predicted gene expression among deep-sea genomes. Gene (2007) 397, 136-142.

23. Bin-Guang Ma*. How to describe genes: enlightenment from the quaternary number system. BioSystems (2007) 90, 20-27.

24. Bin-Guang Ma*, Jian-Xiu Guo, Hong-Yu Zhang*. Direct correlation between proteins' folding rates and their amino acid compositions: an ab initio folding rate prediction. Proteins: Structure, Function, and Bioinformatics (2006) 65, 362-372.

25. Bin-Guang Ma, Qin Song, Hong-Yu Zhang*. CvP-bias as an index to predict the life style of last common ancestor. Journal of Biomolecular Structure & Dynamics, 23 (2006) 555-558.

26. Bin-Guang Ma, Ling-Ling Chen*. The Most Deviated Condon Position in AT-rich genomes: a function related analysis. Journal of Biomolecular Structure & Dynamics (2005), 23, 143-149.

27. Guang-Zhong Wang1, Bin-Guang Ma1, Yan Yang, Hong-Yu Zhang*. Unexpected amino acid composition of modern Reptilia and its implications in molecular mechanisms of dinosaur extinction. Biochemical & Biophysical Research Communications (2005) 333, 1047-1049.

28. Ling-Ling Chen, Bin-Guang Ma, Na Gao. Reannotation of hypothetical ORFs in plant pathogen Erwinia carotovora subsp. atroseptica SCRI1043. FEBS Journal (2008) 275, 198-206.

29. Hong-Fang Ji, De-Xin Kong, Liang Shen, Ling-Ling Chen, Bin-Guang Ma, Hong-Yu Zhang*. Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery. Genome Biology (2007) 8:R176.

30. Hao Wu, Bin-Guang Ma, Ji-Tao Zhao and Hong-Yu Zhang*. How similar are amino acid mutations in human genetic diseases and evolution. Biochemical & Biophysical Research Communications (2007) 362, 233-237.

31. Hao Wu, Yan Yang, Sheng-Juan Jiang, Ling-Ling Chen, Hai-Xia Gao, Qing-Shan Fu, Feng Li, Bin-Guang Ma, Hong-Yu Zhang. DCCP and DICP: construction and analyses of databases for copper- and iron-chelating proteins. Genomics Proteomics Bioinformatics (2005) 3, 52-57.

32. 徐宏睿, 马彬广* 蛋白质折叠速率决定因素与预测方法的研究进展 生物物理学报(2013)Vol. 29 (3): 192-202.

33. 郭建秀,马彬广,张红雨* 蛋白质折叠速率预测研究进展 生物物理学报 2006 Vol. 22 (2): 89-95.

34. 马彬广 原核基因识别中的一种负样本生成算法 《天津理工学院学报》 2004年01期






专著章节:

马彬广、郝保海、胡晓攀、王双寅,中国微生物基因组研究(章节“原核微生物的温度适应机制:组学视角” pp: 400-413),科学出版社,2012.

李友国、王善明、彭杰丽、马彬广,中国微生物基因组研究(章节“根瘤菌功能基因组学研究概述”pp: 166-180),科学出版社,2012.




学术会议(论文/摘要/展报/报告):

The 16th International Conference on Systems Biology (ICSB 2015), November 23-26, 2015, Biopolis, Singapore, Abstract&Poster: "Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability".

Genomics Frontiers Symposium, July 16-19, 2015, Beijing, Abstract: "Spatial Organization of E. coli Transcriptional Regulatory Network".

The Twelfth International Bioinformatics Workshop (IBW2015), July 9-10, 2015, Harbin, China, Abstract: "Metabolic Channeling: Integrated Analysis of Human Cancer Protein-protein Interaction and Metabolic Networks".

The 2nd International SystemsX.ch Conference on Systems Biology, Oct, 2014,  Lausanne, Switzerland, Abstract&Poster: "Spatial Features for Escherichia coli Genome Organization".

The 15th International Systems Biology Conference, Sep, 2014, Melbourne, Australia, Abstract&Poster: "Construction and Simulation of Bradyrhizobium japonicum USDA110 Metabolic Network: New Insights for Symbiotic Nitrogen Fixation Metabolism".

第三届中国微生物基因组学术研讨会,2010年11月,深圳,摘要/报告:"Thermophilic Adaptation of Prokaryotic Genomes".

中国科学院智能计算与生物信息学学术研讨会,2006年11月,合肥,论文/报告:“蛋白质折叠速率计算”。





科研项目:

细菌三维基因组热适应调控机理的系统生物学研究,国家自然科学基金(31570844),主持,2016.1-2019.12

原核基因表达水平热适应调控机理的系统生物学研究,国家自然科学基金(31100602),主持,2012.1-2014.12

蛋白复合物的热稳定性与其亚基表达水平和折叠速率关系的研究,教育部留学回国人员科研启动基金(122064),主持,2012.1-2014.12

生物与非生物因子诱发果实采后衰老的生物学基础,973项目(2013CB127103),学术骨干,参与,2013.1-2017.9

基于振荡器的虚实混合生物回路的构建,校自主标志性成果培育项目(2662016PY094),主持,2016.1-2018.12

微生物代谢途径流平衡分析平台建设及应用,校自主创新基金交叉项目(2013JC009),主持,2013.1-2014.12

原核基因热适应表达水平预测,校自主创新基金培育项目(2011PY070),主持,2011.5-2012.12

根瘤菌蛋白相互作用组的建模与验证,校自主创新基金青年教师项目(2010QC016),主持,2011.1-2012.12

红曲菌中PKS基因的比较基因组学分析及重要基因功能验证,校自主创新基金交叉项目(2011JC009),共同申请人,2011.5-2012.12


此外参与:

基于组学的新药发现技术,湖北省自然科学基金创新群体(2013CFA016),2014-2016
文昌鱼假定基因功能预测与实验验证,863项目(2008AA09Z411)
胡萝卜软腐欧文氏菌功能基因分析及药物靶点初筛,国家自然科学基金项目(30600119)
细胞型朊病毒蛋白错误折叠机理的理论研究,国家自然科学基金项目(30570383)




教改项目:

系统生物学,研究生教育创新工程项目(2010KC06),主持,2010-2012.

合成生物学创新型实验,创新性实验课程项目,主持,2016.


教学论文:

田六、罗旭东、张红雨、马彬广*、金安江*,iGEM竞教结合提升学生科研创新能力及综合素质,高校生物学教学研究(电子版)2016年 6 月,6  (2):  57-62.

马彬广,浅谈师者之“范”的三个层次,(李崇光 江珩主编:《创新方法 卓尔不群:华中农业大学“创新方法 提升质量”教育思想大讨论成果文集》,页: 326-328. 高等教育出版社,北京,2015.12。)
备注 指导大学生竞赛:
iGEM-2015, 指导学生赴美国波士顿参赛,获得金奖,并获得Best Information Processing Project提名。
iGEM-2014, 带队赴美国波士顿参赛,获得金奖。
iGEM-2013, 带队赴香港参赛,获得金奖。
2007年,山东理工大学,指导本科生在“挑战杯”全国大学生课外学术科技作品竞赛中获得二等奖。
2005年,山东理工大学,协助指导本科生在“挑战杯”全国大学生课外学术科技作品竞赛中获得一等奖。
主讲课程:
Bioinformatics (留学生课程,全英语授课),2011年秋,华中农业大学
系统生物学 (研究生课程),自2010年秋开始,华中农业大学, 课程网站:http://ibi.hzau.edu.cn/bgma/sysbio/teaPlan.html
进化与生态 (本科生课程),自2011年春开始,华中农业大学
Python语言编程(本科生课程),自2013年秋开始,华中农业大学
系统与合成生物学(本科生课程),自2014春开始,华中农业大学