马彬广 【教授】
姓名 马彬广 性别
职称 教授 学位 博士
电话 027-87280877 邮箱 mbg@mail.hzau.edu.cn
工作单位 华中农业大学信息学院
研究方向 生物物理学;计算生物学;系统与合成生物学
教育经历 2004.9-2007.6, 苏州大学, 高分子化学与物理(化学生物学方向), 博士
2001.9-2004.6, 天津大学, 生物物理学, 硕士 
1997.9-2001.7, 河北工业大学, 应用物理学, 本科
主要职历 2016.12至今, 华中农业大学信息学院, 教授(博士生导师)
2014.7-2016.12, 华中农业大学信息学院, 副教授
2009.11-2014.7, 华中农业大学生命科学技术学院, 副教授
2007.11-2009.11, Bergen Center for Computational Sciences, Norway(挪威), 博士后

学术兼职:
Nature旗下国际刊物Scientific Reports编委
iGEM国际遗传工程机器设计竞赛2013亚洲赛区评委
第八届国际生物信息研讨会(IBW2010-武汉)组委会程序委员
科研成果 近几年来主要在计算生物学领域从事基因组分析、蛋白质折叠及蛋白质相互作用、微生物热适应的分子机理等方向的研究工作,在Nucleic Acid Res., Structure, PLoS Comput Biol., Sci. Rep., J. Mol. Biol.,Proteins, Genome Biol., BMC Genomics, PLoS One, FEBS J., FEBS Lett., Gene, Biochem. Biophys. Res. Commun.等国际重要期刊发表SCI论文20多篇,其中,关于蛋白质折叠类型预测的JMB论文入选Faculty of 1000 Biology。本人曾受邀担任国内外重要期刊审稿人,例如:Journal of Chemical Information and Modeling, The Open Structural Biology Journal, Journal of Molecular Biology, Journal of Theoretical Biology, Molecular BioSystems, Gene, Genomics, Journal of Biomolecular Structure & Dynamics、生物物理学报等。 


发表论文:(上标1表示并列第一作者,星号* 表示通讯作者)

1. Xie Fuli, Zhao Wenlong, Wang Xiao, Zhang Jing, Hao Baohai, Zou Zhengzheng, Ma Bin-Guang and Li Youguo*, A Genome-Wide Prediction and Identification of Intergenic Small RNAs by Comparative Analysis in Mesorhizobium huakuii 7653R. Frontiers in Microbiology, 2017, 8: 1730. (published: 08 September 2017, doi: 10.3389/fmicb.2017.01730)

2. Xia Wang#, Yuantao Xu#, Siqi Zhang#, Li Cao#, Yue Huang, Junfeng Cheng, Guizhi Wu, Shilin Tian, Chunli Chen, Yan Liu, Huiwen Yu, Xiaoming Yang, Hong Lan, Nan Wang, Lun Wang, Jidi Xu, Xiaolin Jiang, Zongzhou Xie, Meilian Tan, Robert M Larkin, Ling-Ling Chen, Bin-Guang Ma, Yijun Ruan, Xiuxin Deng, Qiang Xu*, Genomic analyses of primitive, wild and cultivated citrus provide insights into asexual reproduction. Nature Genetics 2017, 49: 765- 772.

3. Yi Yang, Xiao-Pan Hu, Bin-Guang Ma*, Construction and simulation of the Bradyrhizobium diazoefficiens USDA110 metabolic network: a comparison between free-living and symbiotic states. Mol. BioSyst., 2017, 13: 607-620.

4. Hong-Rui Xu, Jun-Feng Cheng, Xiao-Pan Hu, Ying-Ying Chu, Bin-Guang Ma*, Are protein hubs faster folders? Exploration based on Escherichia coli proteome. Amino Acids 2016, 48(12): 2747–2753.

5. 马彬广,蛋白折叠预测,科学通报 61(24), 2670-2680 (2016); doi: 10.1360/N972016-00658; (约稿综述,Science125个科学前沿问题系列解读,第58问:Can we predict how proteins will fold?)http://engine.scichina.com/doi/10.1360/N972016-00658

6. Yi-Ming He, Bin-Guang Ma*, Abundance and Temperature Dependency of Protein-Protein Interaction Revealed by Interface Structure Analysis and Stability Evolution. Sci Rep. 2016 May 25; 6:26737.  doi:10.1038/srep26737.

7. Xiao-Pan Hu, Yi Yang, Bin-Guang Ma*, Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability. Sci Rep. 2015 Jun 9; 5:11113. doi: 10.1038/srep11113.

8. Ting Xie1, Liang-Yu Fu1, Qing-Yong Yang1, Heng Xiong1, Hong-Rui Xu, Bin-Guang Ma*, Hong-Yu Zhang*, Spatial features for Escherichia coli genome organization, BMC Genomics. 2015 Feb 5;16:37. doi: 10.1186/s12864-015-1258-1.

9. Heng Xiong, Yi Yang, Xiao-Pan Hu, Yi-Ming He, Bin-Guang Ma*, Sequence determinants of prokaryotic gene expression level under heat stress. Gene 2014, 551: 92-102.

10. Shanming Wang, Baohai Hao, Jiarui Li, Huilin Gu, Jieli Peng, Fuli Xie, Xinyin Zhao, Christian Frech, Nansheng Chen*, Binguang Ma*, Youguo Li*, Whole-genome sequencing of Mesorhizobium huakuii 7653R provides molecular insights into host specificity and symbiosis island dynamics. BMC Genomics 2014, 15:440 (6 June 2014)

11. Jieli Peng, Baohai Hao, Liu Liu, Shanming Wang, Binguang Ma, Yi Yang, Fuli Xie, Youguo Li RNA-Seq and Microarrays Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells. PLoS ONE (2014) 9(4): e93626. doi:10.1371/journal.pone.0093626.

12. Alexander Goncearenco, Bin-Guang Ma, and Igor N. Berezovsky, Molecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins Nucl. Acids Res. (2014) 42 (5): 2879-2892.

13. Qiang Zhu1, Tao Qin1, Ying-Ying Jiang1, Cong Ji1, De-Xin Kong1, Bin-Guang Ma1, Hong-Yu Zhang* Chemical basis of metabolic network organization. PLoS Comput Biol. 2011 (10): e1002214.

14. Liang-Yu Fu, Guang-Zhong Wang, Bin-Guang Ma, Hong-Yu Zhang* Exploring the common molecular basis for the universal DNA mutation bias: revival of Löwdin mutation model.  Biochem Biophys Res Commun. (2011) 409: 367-371.

15. Bin-Guang Ma*, Hong-Yu Zhang* Stoichiometry and Preferential Interaction: Two Components of the Principle for Protein Structure Organization. Journal of Biomolecular Structure & Dynamics. (2011) 28: 619-20; discussion 669-674.

16. Bin-Guang Ma, Igor N. Berezovsky* The MBLOSUM: a server for deriving mutation targets and position-specific substitution rates. Journal of Biomolecular Structure & Dynamics (2010), 28, 415-419.

17. Bin-Guang Ma1, Alexander Goncearenco1, Igor N. Berezovsky* Thermophilic adaptation of protein complexes inferred from proteomic homology modeling. Structure (2010) 18, 819-828.

18. Bin-Guang Ma*, Ling-Ling Chen, Hong-Yu Zhang. FDserver: A web service for protein folding research. NaturePrecedings (2008)

19. Bin-Guang Ma* Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis. Nature Precedings (2008) .

20. Ji Wang, Bin-Guang Ma*, Hong-Yu Zhang, Ling-Ling Chen, Shi-Cui Zhang*. How does gene expression level contribute to thermophilic adaptation of prokaryotes? An exploration based on predictors. Gene (2008) 421, 32-36.

21. Bin-Guang Ma1, Lei Chen1, Hong-Fang Ji, Zhong-Hua Chen, Fu-Rong Yang, Ling Wang, Ge Qu, Ying-Ying Jiang, Cong Ji, Hong-Yu Zhang*. Characters of very ancient proteins. Biochemical & Biophysical Research Communications (2008) 366, 607-611.

22. Bin-Guang Ma*, Ling-Ling Chen, Hong-Yu Zhang*. What determines protein folding type? An investigation of intrinsic structural properties and its implications for understanding folding mechanisms. Journal of Molecular Biology (2007) 370, 439-448. 该论文入选Faculty of 1000 Biology

23. Yan Zhou1, Bin-Guang Ma1, Hong-Yu Zhang*. Human oncogene tissue-specific expression level significantly correlates with sequence compositional features. FEBS Letters (2007) 581, 4361-4365.

24. Ke Xu and Bin-Guang Ma*. Comparative analysis of predicted gene expression among deep-sea genomes. Gene (2007) 397, 136-142.

25. Bin-Guang Ma*. How to describe genes: enlightenment from the quaternary number system. BioSystems (2007) 90, 20-27.

26. Bin-Guang Ma*, Jian-Xiu Guo, Hong-Yu Zhang*. Direct correlation between proteins' folding rates and their amino acid compositions: an ab initio folding rate prediction. Proteins: Structure, Function, and Bioinformatics (2006) 65, 362-372.

27. Bin-Guang Ma, Qin Song, Hong-Yu Zhang*. CvP-bias as an index to predict the life style of last common ancestor. Journal of Biomolecular Structure & Dynamics, 23 (2006) 555-558.

28. Bin-Guang Ma, Ling-Ling Chen*. The Most Deviated Condon Position in AT-rich genomes: a function related analysis. Journal of Biomolecular Structure & Dynamics (2005), 23, 143-149.

29. Guang-Zhong Wang1, Bin-Guang Ma1, Yan Yang, Hong-Yu Zhang*. Unexpected amino acid composition of modern Reptilia and its implications in molecular mechanisms of dinosaur extinction. Biochemical & Biophysical Research Communications (2005) 333, 1047-1049.

30. Ling-Ling Chen, Bin-Guang Ma, Na Gao. Reannotation of hypothetical ORFs in plant pathogen Erwinia carotovora subsp. atroseptica SCRI1043. FEBS Journal (2008) 275, 198-206.

31. Hong-Fang Ji, De-Xin Kong, Liang Shen, Ling-Ling Chen, Bin-Guang Ma, Hong-Yu Zhang*. Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery. Genome Biology (2007) 8:R176.

32. Hao Wu, Bin-Guang Ma, Ji-Tao Zhao and Hong-Yu Zhang*. How similar are amino acid mutations in human genetic diseases and evolution. Biochemical & Biophysical Research Communications (2007) 362, 233-237.

33. Hao Wu, Yan Yang, Sheng-Juan Jiang, Ling-Ling Chen, Hai-Xia Gao, Qing-Shan Fu, Feng Li, Bin-Guang Ma, Hong-Yu Zhang. DCCP and DICP: construction and analyses of databases for copper- and iron-chelating proteins. Genomics Proteomics Bioinformatics (2005) 3, 52-57.

34. 徐宏睿, 马彬广* 蛋白质折叠速率决定因素与预测方法的研究进展 生物物理学报(2013)Vol. 29 (3): 192-202.

35. 郭建秀,马彬广,张红雨* 蛋白质折叠速率预测研究进展 生物物理学报 2006 Vol. 22 (2): 89-95.

36. 马彬广 原核基因识别中的一种负样本生成算法 《天津理工学院学报》 2004年01期






专著章节:

马彬广、郝保海、胡晓攀、王双寅,中国微生物基因组研究(章节“原核微生物的温度适应机制:组学视角” pp: 400-413),科学出版社,2012.

李友国、王善明、彭杰丽、马彬广,中国微生物基因组研究(章节“根瘤菌功能基因组学研究概述”pp: 166-180),科学出版社,2012.




学术会议(论文/摘要/展报/报告):

EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology (5504), June 27-30, 2017, Heidelberg, Germany, Abstract&Poster: "Spatial Organization of Network Motifs in the Transcriptional Regulation Network of Escherichia coli".

The 16th International Conference on Systems Biology (ICSB 2015), November 23-26, 2015, Biopolis, Singapore, Abstract&Poster: "Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability".

Genomics Frontiers Symposium, July 16-19, 2015, Beijing, Abstract: "Spatial Organization of E. coli Transcriptional Regulatory Network".

The Twelfth International Bioinformatics Workshop (IBW2015), July 9-10, 2015, Harbin, China, Abstract: "Metabolic Channeling: Integrated Analysis of Human Cancer Protein-protein Interaction and Metabolic Networks".

The 2nd International SystemsX.ch Conference on Systems Biology, Oct, 2014,  Lausanne, Switzerland, Abstract&Poster: "Spatial Features for Escherichia coli Genome Organization".

The 15th International Systems Biology Conference, Sep, 2014, Melbourne, Australia, Abstract&Poster: "Construction and Simulation of Bradyrhizobium japonicum USDA110 Metabolic Network: New Insights for Symbiotic Nitrogen Fixation Metabolism".

第三届中国微生物基因组学术研讨会,2010年11月,深圳,摘要/报告:"Thermophilic Adaptation of Prokaryotic Genomes".

中国科学院智能计算与生物信息学学术研讨会,2006年11月,合肥,论文/报告:“蛋白质折叠速率计算”。





科研项目:

细菌三维基因组热适应调控机理的系统生物学研究,国家自然科学基金(31570844),主持,2016.1-2019.12

原核基因表达水平热适应调控机理的系统生物学研究,国家自然科学基金(31100602),主持,2012.1-2014.12

蛋白复合物的热稳定性与其亚基表达水平和折叠速率关系的研究,教育部留学回国人员科研启动基金(122064),主持,2012.1-2014.12

生物与非生物因子诱发果实采后衰老的生物学基础,973项目(2013CB127103),学术骨干,参与,2013.1-2017.9

基于振荡器的虚实混合生物回路的构建,校自主标志性成果培育项目(2662016PY094),主持,2016.1-2018.12

微生物代谢途径流平衡分析平台建设及应用,校自主创新基金交叉项目(2013JC009),主持,2013.1-2014.12

原核基因热适应表达水平预测,校自主创新基金培育项目(2011PY070),主持,2011.5-2012.12

根瘤菌蛋白相互作用组的建模与验证,校自主创新基金青年教师项目(2010QC016),主持,2011.1-2012.12

红曲菌中PKS基因的比较基因组学分析及重要基因功能验证,校自主创新基金交叉项目(2011JC009),共同申请人,2011.5-2012.12


此外参与:

基于组学的新药发现技术,湖北省自然科学基金创新群体(2013CFA016),2014-2016
文昌鱼假定基因功能预测与实验验证,863项目(2008AA09Z411)
胡萝卜软腐欧文氏菌功能基因分析及药物靶点初筛,国家自然科学基金项目(30600119)
细胞型朊病毒蛋白错误折叠机理的理论研究,国家自然科学基金项目(30570383)




教改项目:

系统生物学,研究生教育创新工程项目(2010KC06),主持,2010-2012.

合成生物学创新型实验,创新性实验课程项目,主持,2016.


教学论文:

田六、罗旭东、张红雨、马彬广*、金安江*,iGEM竞教结合提升学生科研创新能力及综合素质,高校生物学教学研究(电子版)2016年 6 月,6  (2):  57-62.

马彬广,浅谈师者之“范”的三个层次,(李崇光 江珩主编:《创新方法 卓尔不群:华中农业大学“创新方法 提升质量”教育思想大讨论成果文集》,页: 326-328. 高等教育出版社,北京,2015.12。)
备注 指导大学生竞赛:
iGEM-2015, 指导学生赴美国波士顿参赛,获得金奖,并获得Best Information Processing Project提名。
iGEM-2014, 带队赴美国波士顿参赛,获得金奖。
iGEM-2013, 带队赴香港参赛,获得金奖。
2007年,山东理工大学,指导本科生在“挑战杯”全国大学生课外学术科技作品竞赛中获得二等奖。

2005年,山东理工大学,协助指导本科生在“挑战杯”全国大学生课外学术科技作品竞赛中获得一等奖。


主讲课程:
Bioinformatics (留学生课程,全英语授课),2011年秋,华中农业大学
系统生物学 (研究生课程),自2010年秋开始,华中农业大学, 课程网站:http://ibi.hzau.edu.cn/bgma/sysbio/teaPlan.html
进化与生态 (本科生课程),自2011年春开始,华中农业大学
Python语言编程(本科生课程),自2013年秋开始,华中农业大学
系统与合成生物学(本科生课程),自2014春开始,华中农业大学